Scientific documentation is growing so rapidly that it poses a daunting challenge for scientists to find new applications, new domain links and new fields of study. Even with keyword-based search tools, conventional literature review approaches are inadequate for scaling up to cover large volumes of research and systematically reveal research gaps or grounded hypotheses. This paper introduces AgentSci, a novel multi-agent framework that combines the functionalities of Large Language Models (LLMs), Knowledge Graph Reasoning (KGR) and co-operative multi-agent models to enable automatic scientific discovery pipeline. AgentSci consists of five specialised agents which collaboratively process a corpus of research papers to derive ranked, actionable and novel research hypotheses: Literature Mining Agent, Knowledge Graph Builder, Gap Discovery Agent, Hypothesis Generation Agent and a Validation Agent. To measure the quality and usefulness of the outputs generated, we introduce a composite scoring model that combines five different scores: Knowledge Relevance Score (KRS), Research Gap Score (RGS), Hypothesis Novelty Index (HNI), Agent Consensus Score (ACS), and Scientific Discovery Potential (SDP). The accuracy in gap detection, novelty of hypothesis, and relevance of the research are significantly improved by AgentSci over the conventional retrieval based systems in four scientific research areas demonstrated through experiments. AgentSci is a step towards fully automatic scientific discovery, brought by AI.
Keywords : Multi-Agent Systems, LLM, Knowledge Graph Reasoning, Scientific Discovery, Hypothesis Generation.
Authors : Sriharsha Chollangi
Title : AgentSci: A Multi-Agent Scientific Discovery Framework Using Knowledge Graph Reasoning and Large Language Models
Volume/Issue : 2026;3(3 ( July - September ))
Page No : 1 - 8